ELK4 Promotes Vasculogenic Mimicry in Oral Squamous Cell Carcinoma via Driving <i>DHFR</i> Transcriptional Activation
<i>DHFR</i> was a pivotal enhancer-regulated gene driving VM and metastasis in OSCC. ELK4 directly binds to <i>DHFR</i> enhancer regions to activate its transcription, thereby promoting these malignant phenotypes. These findings identified the ELK4/DHFR axis as a promising therapeutic target for anti-angiogenic intervention in OSCC.
Authors
- Yang Bai (ORCID: https://orcid.org/0000-0002-4420-4553)
- Yongle Qiu (ORCID: https://orcid.org/0000-0002-5118-815X)
- Jilun Liu
- Kunshan Li (ORCID: https://orcid.org/0000-0002-0316-1753)
- Fei Xu (ORCID: https://orcid.org/0000-0003-2851-5615)
- Wenjing Wang (ORCID: https://orcid.org/0000-0001-8522-078X)
- Jie Guo (ORCID: https://orcid.org/0000-0002-6778-7974)
- Wenjuan Zhang (ORCID: https://orcid.org/0000-0002-8850-5235)
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-12-04
- DOI
- https://doi.org/10.32604/or.2025.069612
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00