Associations of growth differentiation factor 15 with kidney function in frail and pre-frail older individuals: the mediating role of inflammation and oxidative stress
Our findings suggest that high levels of GDF-15 are associated with lower eGFR in frail and pre-frail older individuals. GDF-15 may be related to kidney function through its involvement in inflammatory and oxidative stress responses.
Authors
- Qiang Gao (ORCID: https://orcid.org/0000-0002-9323-1101)
- Zehong Huo
- Yingqi Zhao (ORCID: https://orcid.org/0009-0003-4624-9944)
- Anying Bai (ORCID: https://orcid.org/0000-0002-3121-1228)
- Yuting Kang (ORCID: https://orcid.org/0000-0003-1355-9949)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-6944-2021)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-1886-8225)
- Yushan Zhang (ORCID: https://orcid.org/0000-0003-0601-5898)
- Ping Zeng (ORCID: https://orcid.org/0000-0003-2919-1974)
- Hong Shi (ORCID: https://orcid.org/0000-0003-3776-498X)
- Ji Shen (ORCID: https://orcid.org/0000-0003-3267-3261)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Geriatric Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s40001-025-03619-8
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00