Breakthrough ventricular fibrillation in a patient with catecholaminergic polymorphic ventricular tachycardia after a decade of stability: A follow-up report

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a rare but potentially fatal genetic arrhythmia disorder characterized by ventricular tachycardia that is primarily triggered by physical exertion or emotional stress with associated elevations in adrenergic tone. The hallmark arrhythmia is bidirectional or polymorphic ventricular tachycardia (VT), which can deteriorate into ventricular fibrillation (VF), leading to syncope or sudden cardiac death.1 CPVT is most commonly linked to mutations in the RYR2 (autosomal dominant) or CASQ2 (autosomal recessive) genes, both of which impair calcium handling in cardiomyocytes.