Megalin (LRP2) Expression Patterns in Prostate Cancer Stem Cells and Metastatic Subtypes: Implications for Tumor Progression and Metabolism
LRP2 shows subtype-specific expression patterns in PCa, with elevated levels in DU-145 CSCs and metastatic tumors. Its link to metabolic pathways and inverse relationship with AR suggest a potential role in therapy resistance and metastasis.
Authors
- Çığır Biray Avcı (ORCID: https://orcid.org/0000-0001-8251-4520)
- Günel Mukhtarova (ORCID: https://orcid.org/0000-0003-3374-9272)
- Aysegul Murat
- Eda Açıkgöz (ORCID: https://orcid.org/0000-0002-6772-3081)
- Hüseyin Aktuğ (ORCID: https://orcid.org/0000-0003-4150-8495)
- Gülperi Öktem (ORCID: https://orcid.org/0000-0003-1914-2503)
Institutions
- Van Yüzüncü Yıl Üniversitesi (TR)
- The University of Texas MD Anderson Cancer Center (US)
- Ege University (TR)
Publication Details
- Journal
- The Prostate
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1002/pros.70105
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00