Protein dynamics-assisted engineering of a selective debenzylase for replacing Pd/C-catalyzed debenzylation in statin precursor synthesis
This work presents the first enzymatic debenzylation as a green alternative to Pd/C-catalyzed hydrogenation. Using CoDyPAM approach, dynamic conformational analyses identify challenging distal hotspots for enzyme engineering.
Authors
- Jianfeng Lin (ORCID: https://orcid.org/0000-0001-5732-1209)
- Xuri Wu (ORCID: https://orcid.org/0000-0002-0933-5902)
- Yijun Chen (ORCID: https://orcid.org/0000-0002-4920-152X)
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Green Chemistry
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1039/d5gc05033b
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.00