Deciphering OCT4A-dose-dependent transcriptional profiles associated with tumorigenic potential in somatic cancer cells
Our findings further confirm in SCCs that the functional pleiotropy of OCT4A is closely linked to its protein abundance, and further systematically elucidate the molecular signatures of OCT4A-regulated downstream gene networks associated with tumorigenic phenotypes at differential protein levels, providing novel insights for its translational exploitation in both oncological intervention and regenerative medicine strategies.
Authors
- Guozhong Gong (ORCID: https://orcid.org/0000-0002-1824-1625)
- Bo He (ORCID: https://orcid.org/0000-0002-4029-5435)
- Min Tang (ORCID: https://orcid.org/0000-0002-6084-1827)
- Yongfang Jiang (ORCID: https://orcid.org/0000-0001-7415-4289)
- Chen Cheng (ORCID: https://orcid.org/0000-0002-0893-1948)
- Sujuan Wang (ORCID: https://orcid.org/0000-0002-4735-6341)
- Guangdi Li (ORCID: https://orcid.org/0000-0002-4841-3803)
- Ning Zhou (ORCID: https://orcid.org/0000-0002-4929-3575)
- Yanwen Zhou
- Rui Liang (ORCID: https://orcid.org/0009-0004-6748-5142)
- Zhenyu Wu (ORCID: https://orcid.org/0000-0003-4345-5075)
- Xinqiang Xiao
Institutions
- Central South University (CN)
Publication Details
- Journal
- SLAS TECHNOLOGY
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.slast.2025.100381
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00