Safety and Effectiveness of Long-Term Isoniazid Treatment for the Prevention of Tuberculosis in High-Risk Dialysis Patients
Long-term IPT significantly reduced the incidence of TB in a high-risk cohort with CKD-5D. IPT was safe and well-tolerated, with < 10% of patients discontinuing therapy because of adverse events, which were generally mild and reversible. These findings provide strong real-world evidence supporting IPT use in TB-endemic dialysis populations.
Authors
- Robert Freercks (ORCID: https://orcid.org/0000-0002-7939-1352)
- Savania Nagiah (ORCID: https://orcid.org/0000-0002-7614-8226)
- Jason Ensor (ORCID: https://orcid.org/0009-0000-1690-9452)
- Elizabeth van der Merwe (ORCID: https://orcid.org/0000-0002-4628-8885)
- Elmi Muller (ORCID: https://orcid.org/0000-0003-4891-5296)
- Siviwe Ndamase
- Noel Walton
- Andrew D. Redd (ORCID: https://orcid.org/0000-0003-4651-1423)
- Kathryn Manning (ORCID: https://orcid.org/0000-0003-4213-2522)
Institutions
- Johns Hopkins University (US)
- University of Cape Town (ZA)
- Stellenbosch University (ZA)
- Johns Hopkins Medicine (US)
- Groote Schuur Hospital (ZA)
- Livingstone Hospital (ZA)
- National Institute of Allergy and Infectious Diseases (US)
- Nelson Mandela University (ZA)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.ekir.2025.11.038
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00