Viral peptides remodel the tumor immune microenvironment of cold tumors with RNA-seq insights
This study demonstrates a peptide-based platform to remodel cold tumor immune microenvironments. Integration of transcriptomic profiling provides mechanistic insights and establishes a robust workflow for evaluating immunomodulatory technologies. This tumor-agnostic approach may enhance anti-tumor immunity and improve immunotherapy efficacy in cold tumors.
Authors
- Linlang Guo (ORCID: https://orcid.org/0000-0002-1859-7592)
- Mengchuan Wang (ORCID: https://orcid.org/0000-0003-4172-7583)
- Yujing Liu (ORCID: https://orcid.org/0000-0002-0250-9631)
- Yiteng Chen
- Pengkhun Nov (ORCID: https://orcid.org/0000-0002-7016-8285)
- Hong Zhu (ORCID: https://orcid.org/0000-0002-5555-1227)
- Peng Zhang (ORCID: https://orcid.org/0000-0003-3481-9439)
- Qian Chen (ORCID: https://orcid.org/0000-0002-8566-4847)
- Hao Tang (ORCID: https://orcid.org/0000-0002-3932-4016)
- Wulikaixi Yagufu
- Mohsin Farid Sulehri
Institutions
- Zhujiang Hospital (CN)
Publication Details
- Journal
- SLAS TECHNOLOGY
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.slast.2025.100379
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00