Perioperative Nicotine for Postoperative Pain and Nausea: A Systematic Review with Clinical and Methodological Insights
Although perioperative nicotine administration demonstrated reductions in postoperative pain, nausea, vomiting, and opioid consumption in some studies, the effect of nicotine on PONV was inconsistent. Variability in patient populations, dosage forms, and dosages complicates the formulation of definitive clinical recommendations. Overall, perioperative nicotine shows promise for improving postoperative pain management, but its impact on PONV requires careful consideration. Nicotine administration has been investigated as an analgesic adjunct and as a strategy for preventing PONV. This systematic review aimed to determine the effect of perioperative nicotine administration on postoperative pain and PONV.
Authors
- Feras Twfeq Almogbel
- Mohammed Alghamdi (ORCID: https://orcid.org/0000-0002-9794-554X)
- Abdulrahman Alharbi (ORCID: https://orcid.org/0009-0003-7559-3533)
- Saud S. Alotaibi (ORCID: https://orcid.org/0000-0003-1082-513X)
- Rawan Fauzy Allehyani
- Lama Zaid Alzimami
- Mona Jalal Awaji
- Ali Mohamed Elkarouri
- Layan Saud Almutairy
- Atheer Alkhalil Medkhali
- Reem Abduldaem Aloufi
- Jawaher Hani Alabdualqader
Institutions
- University of Medical Sciences and Technology (SD)
- Umm al-Qura University (SA)
- Taibah University (SA)
- King Faisal Specialist Hospital & Research Centre (SA)
- King Abdulaziz Medical City (SA)
- Dammam Central Hospital (SA)
- Batterjee Medical College
- King Faisal University (SA)
- Jazan University (SA)
Publication Details
- Journal
- Anesthesiology and Pain Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.5812/aapm-164878
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00