PNPLA3 I148M is unrelated to HCC occurrence but associates with poorer tumor differentiation in Korean MASLD: a prospective cohort of 562 patients
The PNPLA3 I148M GG genotype was not significantly associated with increased HCC occurrence in Korean MASLD patients within the present cohort. Although the GG genotype is known to play a role in development and progression of MASLD, further studies are warranted to clarify its contribution to tumor initiation and dedifferentiation.
Authors
- S. Cho (ORCID: https://orcid.org/0000-0003-0983-0927)
- Keungmo Yang (ORCID: https://orcid.org/0000-0001-8966-9242)
- Jung Hoon (ORCID: https://orcid.org/0000-0001-7499-8377)
- Mi Yeon Byun (ORCID: https://orcid.org/0000-0001-5518-1812)
- Pil Soo Sung (ORCID: https://orcid.org/0000-0002-5780-9607)
- Seong Wook Yang (ORCID: https://orcid.org/0000-0002-0100-4594)
- Si Hyun Bae (ORCID: https://orcid.org/0000-0003-1727-7842)
- Hyun Yang (ORCID: https://orcid.org/0000-0001-6588-9806)
- Jaejun Lee (ORCID: https://orcid.org/0000-0003-4402-9350)
- Dong Yeop Lee (ORCID: https://orcid.org/0000-0002-5513-5389)
- Hee Sun Cho (ORCID: https://orcid.org/0009-0001-6587-5081)
Institutions
- Yonsei University (KR)
- National Institute of Environmental Research (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Journal of Liver Cancer
- Published
- 2025-12-04
- DOI
- https://doi.org/10.17998/jlc.2025.11.16
- Primary Topic
- Genomic variations and chromosomal abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ministry of Science and ICT, South Korea
- Korean Association for the Study of the Liver