Transcriptome analysis unveils Th1 cell cycle signature as a distinctive feature of mixed connective tissue disease
Transcriptome analysis of peripheral blood immune cells revealed that MCTD Th1 cells share many transcriptional features with those in SLE, yet display distinctive cell cycle signature. Particularly, upregulation of cell cycle pathways was associated with characteristic clinical features of MCTD, such as positivity for anti-U1-RNP antibodies and Raynaud's phenomenon. This Th1 cell cycle signature holds promise for shedding light on the underlying pathophysiology of MCTD.
Authors
- Hirofumi Shoda (ORCID: https://orcid.org/0000-0002-1536-0303)
- Tomohisa Okamura (ORCID: https://orcid.org/0000-0001-7257-5557)
- Yasuo Nagafuchi (ORCID: https://orcid.org/0000-0002-1316-8035)
- Yuichi Suwa
- Saeko Yamada (ORCID: https://orcid.org/0000-0001-8561-4463)
- Yumi Tsuchida (ORCID: https://orcid.org/0000-0003-3236-6157)
- Junko Maëda (ORCID: https://orcid.org/0000-0001-5792-9636)
- Mineto Ota (ORCID: https://orcid.org/0000-0003-4552-8573)
Institutions
- Jichi Medical University (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Tokyo Fuji University (JP)
- Tokyo Medical University Hospital (JP)
- Jichi Medical University Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s13075-025-03707-4
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00