Anchor-based evaluation of digital motor biomarkers from a 2-year observation in 100 patients with multiple sclerosis
Our findings yield a well-applicable set of DMO that may support definitions of disability accumulation in (early) pwMS. Establishing patient relevance remains challenging due to expectedly low clinical progression rates. The distinct patterns captured by EDSS and MSWS-12 definitions underline the need for multiple anchors when validating new biomarkers. Trial registration ClinicalTrials.gov, NCT04993274, 2021-03-09 retrospectively registered.
Authors
- Sophia Rekers (ORCID: https://orcid.org/0000-0002-6161-6621)
- Radina Arsenova (ORCID: https://orcid.org/0000-0003-3116-0464)
- Pia S. Sperber (ORCID: https://orcid.org/0000-0002-9534-2374)
- Eva-Maria Dorsch (ORCID: https://orcid.org/0009-0002-5872-1268)
- Gilberto Solorza Buenrostro
- Hanna Marie Röhling (ORCID: https://orcid.org/0000-0002-3106-5830)
- Patrick Schindler (ORCID: https://orcid.org/0000-0002-8846-121X)
- Martin Weygandt (ORCID: https://orcid.org/0000-0001-9962-4582)
- Alexander U. Brandt (ORCID: https://orcid.org/0000-0002-9768-014X)
- Judith Bellmann–Strobl (ORCID: https://orcid.org/0000-0003-2615-1643)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Frederike Cosima Oertel (ORCID: https://orcid.org/0000-0003-4906-5983)
- Tanja Schmitz‐Hübsch (ORCID: https://orcid.org/0000-0003-4833-5937)
- Tatiana Usnich (ORCID: https://orcid.org/0000-0001-7335-8888)
- Sophie K. Piper (ORCID: https://orcid.org/0000-0002-0147-8992)
- Daniel Kroneberg
- Carla A. Ellinghaus (ORCID: https://orcid.org/0009-0007-6790-656X)
Institutions
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Einstein Center Digital Future (DE)
- Zimmer Biomet (Germany) (DE)
- Pathodiagnostik Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1007/s00415-025-13541-y
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Children's Research Centre
- Deutsche Forschungsgemeinschaft