Integrating single-cell RNA-Seq and machine learning to dissect a novel Palmitoylation-related prognostic signature of glioblastoma

This study revealed for the first time the heterogeneity of palmitoylation at the GBM single-cell level. The identification of ZDHHC2, ZDHHC4, and ZDHHC20 as key regulators of palmitoylation in GBM emphasized their potential as biomarkers and therapeutic targets.

Authors

Zhu Zhang (ORCID: https://orcid.org/0000-0002-7489-6917)
Yang Chunli
Zhiying Lin (ORCID: https://orcid.org/0000-0002-6338-5628)
Haojie Zheng

Institutions

First Affiliated Hospital of Jiangxi Medical College (CN)
The First People's Hospital of Shunde (CN)
Jiangxi Provincial People's Hospital (CN)
Zhongshan People's Hospital (CN)

Publication Details

Journal: BMC Neurology
Published: 2025-12-04
DOI: https://doi.org/10.1186/s12883-025-04551-4
Primary Topic: Single-cell and spatial transcriptomics
Type: article
Field-Weighted Citation Impact: 0.00

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article

Integrating single-cell RNA-Seq and machine learning to dissect a novel Palmitoylation-related prognostic signature of glioblastoma

Zhu Zhang, Yang Chunli, Zhiying Lin, Haojie Zheng

Dec 4, 2025

BMC Neurology

Single-cell and spatial transcriptomics

article

Integrating single-cell RNA-Seq and machine learning to dissect a novel Palmitoylation-related prognostic signature of glioblastoma

Zhu Zhang, Yang Chunli, Zhiying Lin, Haojie Zheng

December 4, 2025article en

Abstract

This study revealed for the first time the heterogeneity of palmitoylation at the GBM single-cell level. The identification of ZDHHC2, ZDHHC4, and ZDHHC20 as key regulators of palmitoylation in GBM emphasized their potential as biomarkers and therapeutic targets.

BMC NeurologyVol. 26(1)

First Affiliated Hospital of Jiangxi Medical College (CN), The First People's Hospital of Shunde (CN), Jiangxi Provincial People's Hospital (CN), Zhongshan People's Hospital (CN)

Openalex Percentile: Top 65%

Single-cell and spatial transcriptomics

DOI Open Access PDF OpenAlex

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