Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation
Gal-1 protects against atherosclerosis associated with reprogramming macrophages and tuning T cell immunity through glycan-dependent and -independent pathways.
Authors
- Julian Leberzammer (ORCID: https://orcid.org/0000-0002-1717-0706)
- Alexander Bartelt (ORCID: https://orcid.org/0000-0001-7840-3991)
- Wolfgang Enard (ORCID: https://orcid.org/0000-0002-4056-0550)
- Herbert Kaltner (ORCID: https://orcid.org/0000-0003-4680-8411)
- Veit Eckardt (ORCID: https://orcid.org/0000-0002-8786-1967)
- LI Ya (ORCID: https://orcid.org/0000-0002-1617-8124)
- Michael Lacy (ORCID: https://orcid.org/0000-0001-5944-582X)
- Rundan Duan
- Yvonne Jansen (ORCID: https://orcid.org/0000-0002-1283-8260)
- Yvonne Döring (ORCID: https://orcid.org/0000-0001-9307-3396)
- Xavier Blanchet (ORCID: https://orcid.org/0000-0001-7936-3848)
- Philipp von Hundelshausen (ORCID: https://orcid.org/0000-0001-7474-9370)
- Joel Guerra (ORCID: https://orcid.org/0000-0002-7149-3784)
- Michael Hristov
- Jürgen Bernhagen (ORCID: https://orcid.org/0000-0003-2996-2652)
- Dorothee Atzler (ORCID: https://orcid.org/0000-0002-6551-1544)
- Donato Santovito (ORCID: https://orcid.org/0000-0003-1811-4746)
- Anna-Kristin Ludwig
- Eva Briem (ORCID: https://orcid.org/0009-0003-7506-3882)
- Rui Su (ORCID: https://orcid.org/0000-0002-4807-6229)
- Anna Jung (ORCID: https://orcid.org/0009-0004-0756-8050)
- Vasiliki Triantafyllidou
Institutions
- Goethe University Frankfurt (DE)
- University of Bern (CH)
- University Hospital of Bern (CH)
- Helmholtz Zentrum München (DE)
- Munich Cluster for Systems Neurology (DE)
- German Centre for Cardiovascular Research (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120608
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- China Scholarship Council