Rescue percutaneous coronary intervention in the pharmaco-invasive era of ST-elevation myocardial infarction: insights from the STREAM-2 trial
Contemporary PI with half-dose tenecteplase in older patients requiring rescue intervention led to less ST resolution and worse 30-day outcomes compared to those with successful fibrinolysis receiving scheduled angiography. Notably, delays to deploying rescue PCI in CH patients were shortened over those previously achieved thereby resulting in similar outcomes to those randomized in the ambulance. Our results reinforce the benefits of functional hub and spoke models with rapid transfer to a PCI-capable facility.
Authors
- Robert C. Welsh (ORCID: https://orcid.org/0000-0003-2613-9142)
- Kris Bogaerts (ORCID: https://orcid.org/0000-0003-0188-8665)
- Kevin R. Bainey (ORCID: https://orcid.org/0000-0002-5458-4617)
- Paul W. Armstrong (ORCID: https://orcid.org/0000-0002-0460-3445)
- Peter Sinnaeve (ORCID: https://orcid.org/0000-0003-4716-5892)
- Yves Lambert (ORCID: https://orcid.org/0000-0002-8108-9881)
- О. В. Аверков (ORCID: https://orcid.org/0000-0002-3010-755X)
- Frans Van de Werf (ORCID: https://orcid.org/0000-0001-9479-7767)
- Arsen Ristić (ORCID: https://orcid.org/0000-0002-0713-1180)
- Cynthia M. Westerhout (ORCID: https://orcid.org/0000-0003-1082-5981)
- Yinggan Zheng (ORCID: https://orcid.org/0009-0009-2246-3683)
- Alexandra Arias-Mendoza (ORCID: https://orcid.org/0000-0003-3738-6253)
Institutions
- University of Alberta (CA)
- Pirogov Russian National Research Medical University (RU)
- University of Belgrade (RS)
- Canadian VIGOUR Centre (CA)
- Vietnam National Children's Hospital (VN)
- Centre Hospitalier de Versailles (FR)
- Hasselt University (BE)
- KU Leuven (BE)
Publication Details
- Journal
- European Heart Journal Acute Cardiovascular Care
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1093/ehjacc/zuaf158
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00