Optimized Magnetic Resonance <scp>T1</scp> Mapping for Estimation of Intrathecal Contrast Concentrations in Human Brain and Ventricular Cerebrospinal Fluid
Optimizing a standard Look-Locker T1 mapping protocol allowed for estimation of reliable T1 times in both brain parenchyma and ventricular CSF, and the subsequent determination of concentrations of intrathecal CSF tracer in the human brain, supporting its potential for studying glymphatic function. However, limitations with estimation of T1 times and the selection of relaxivity constant of the contrast agent reduce accuracy of concentration estimates.
Authors
- Kyrre E. Emblem (ORCID: https://orcid.org/0000-0002-6580-9519)
- Geir Ringstad (ORCID: https://orcid.org/0000-0003-0919-4510)
- Per Kristian Eide (ORCID: https://orcid.org/0000-0001-6881-9280)
- Svein Are Sirirud Vatnehol (ORCID: https://orcid.org/0000-0002-7900-0534)
- Trygve Holck Storås
- Lars Magnus Valnes (ORCID: https://orcid.org/0000-0001-9283-5563)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Sørlandet Hospital Arendal (NO)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1002/mrm.70203
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00