Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway
UCHL5 activates the PI3K/AKT/mTOR cascade, which enhances the glycolysis of RCC cells and promotes the development of renal cancer. This study provides insights into the molecular mechanisms underlying the oncogenic role of UCHL5 in RCC.
Authors
- Lin Ruan
- Li Shun (ORCID: https://orcid.org/0000-0003-3787-4281)
- Liuyu Xu
Institutions
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2025-12-04
- DOI
- https://doi.org/10.25259/cytojournal_100_2025
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00