Evolution of proteolysis-targeting chimeras (PROTAC) technology to overcome challenges of antimicrobial resistance
Targeted protein degradation (TPD) is an innovative therapeutic approach that bypasses traditional drug inhibition methods. Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that harness degradation machinery to remove target proteins. This review examines the evolution of PROTACs and their application in targeting microorganisms that develop drug resistance, covering their development, advancements in linker design, E3 ligase selection, and delivery methods, including nanoparticles and exosomes.
Authors
- Ritesh Bhole (ORCID: https://orcid.org/0000-0003-4088-7470)
- Rupesh V. Chikhale (ORCID: https://orcid.org/0000-0001-5622-3981)
- Pramod Khedekar (ORCID: https://orcid.org/0000-0001-7821-3039)
- Dhanashree N. Sarwan
Institutions
- Rashtrasant Tukadoji Maharaj Nagpur University (IN)
- The London College (GB)
- University College London (GB)
Publication Details
- Journal
- npj Antimicrobials and Resistance
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1038/s44259-025-00136-w
- Citations
- 1
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- School of Pharmacy, University College London