A novel biochip-based liquid biopsy for extracellular vesicle RNA detection in prostate cancer
The TCLN biochip enables sensitive, amplification-free detection of EV RNA biomarkers from serum and urine. Key markers such as miR-141, miR-375, and PCA3 showed strong diagnostic and risk stratification value in PCa. This non-invasive approach holds promise for improving early detection and clinical risk assessment.
Authors
- Bingbing Zhu
- Lei Zhou (ORCID: https://orcid.org/0000-0002-0600-2387)
- Zhuo Li (ORCID: https://orcid.org/0000-0001-8774-0471)
- Jiayun Liu (ORCID: https://orcid.org/0000-0003-0293-247X)
- Ani Nan
- Juan Wang (ORCID: https://orcid.org/0000-0001-6321-3562)
- Rui Li (ORCID: https://orcid.org/0000-0003-2318-9232)
- Yang Liu (ORCID: https://orcid.org/0000-0002-1161-6148)
- Yanjun Diao (ORCID: https://orcid.org/0000-0003-1508-8124)
- Jinjie Li (ORCID: https://orcid.org/0000-0002-4439-6276)
- Ting Ding
- Xiaoke Hao (ORCID: https://orcid.org/0009-0004-9569-4638)
Institutions
- Northwest Women's and Children's Hospital (CN)
- Xi'an Medical University (CN)
- Xijing Hospital (CN)
- Xiamen Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Cancer Biology & Therapy
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1080/15384047.2025.2593744
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81