Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome
Increasing circulating ketone levels did not alleviate the cardiac hypertrophy in TazKD mice, suggesting that such an approach would not improve outcomes in BTHS.
Authors
- Gavin Y. Oudit (ORCID: https://orcid.org/0000-0002-9154-9028)
- John R. Ussher (ORCID: https://orcid.org/0000-0001-9574-5707)
- Christina T. Saed (ORCID: https://orcid.org/0000-0002-4469-330X)
- Farah Eaton (ORCID: https://orcid.org/0000-0002-8251-8908)
- Sandra T. Davidge (ORCID: https://orcid.org/0000-0002-5559-4905)
- Amanda A. Greenwell (ORCID: https://orcid.org/0000-0003-0355-2938)
- Linyue Dong
- Ruth Han
- Jordan S. F. Chan (ORCID: https://orcid.org/0009-0006-1567-8772)
- Jennifer Kruger
- Magnus J. Stenlund (ORCID: https://orcid.org/0009-0006-7009-2168)
- Seyed Amirhossein Tabatabaei Dakhili
- Keshav Gopal (ORCID: https://orcid.org/0000-0002-3320-2990)
- Tanin Shafaati
- Sally R. Ferrari
Institutions
- University of Alberta (CA)
- Women and Children’s Health Research Institute (CA)
Publication Details
- Journal
- Journal of Pharmacy & Pharmaceutical Sciences
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/jpps.2025.15688
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00