Sex differences in reward network activation are linked to problematic substance use among high-risk adolescents
This study offers insight into sex differences in risky decision-making neural mechanisms and SUD risk among youth with EXT disorders. Our findings suggest typical risk signaling in the reward-processing network (nucleus accumbens and subgenual anterior cingulate cortex) may protect against substance use, particularly in females with EXT disorders. These findings emphasize the need for further sex-specific research and interventions for youth with EXT disorders.
Authors
- Leslie A. Hulvershorn (ORCID: https://orcid.org/0000-0001-5827-4889)
- Michael P. Smoker (ORCID: https://orcid.org/0000-0002-6515-7362)
- Paola P. Mattey‐Mora (ORCID: https://orcid.org/0000-0003-1499-7422)
- Joseph Aloi
- Olivia Murray (ORCID: https://orcid.org/0000-0002-4648-3138)
- Sydney Lovins
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Advances in Drug and Alcohol Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/adar.2025.14591
- Primary Topic
- Neural and Behavioral Psychology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences