Ultraviolet A1 phototherapy for improvement of hand function in scleroderma: a blinded prospective study
Effective tools for improving sclerotic hand changes in patients with systemic sclerosis are lacking; thus, we conducted a single-blind prospective randomized clinical trial investigating the impact of UVA1 phototherapy on scleroderma of the hands. Seven patients were unilaterally treated, and we found no evidence of significant change in Hand Mobility in Scleroderma (HAMIS) scores after 30 treatments. However, patients did report significant health-related outcome changes in the emotional, symptomatic and functional domains of Skindex-16 [β = –34.1 (95% CI –47.0 to –21.3), –26.3 (–38.1 to –14.4) and –13.1 (–20.9 to –5.41), respectively].
Authors
- Laurel Gray (ORCID: https://orcid.org/0000-0002-4159-1420)
- Zachary Hopkins (ORCID: https://orcid.org/0000-0001-7248-3281)
- Amber Jimenez (ORCID: https://orcid.org/0000-0002-6408-5504)
- Christopher B. Hansen (ORCID: https://orcid.org/0000-0002-2248-4646)
- Tracy Frech (ORCID: https://orcid.org/0000-0002-5472-3840)
- Vikram N. Sahni (ORCID: https://orcid.org/0000-0001-8126-1736)
- Rachel Seifert (ORCID: https://orcid.org/0000-0002-2488-2445)
- Christiaan H Noot (ORCID: https://orcid.org/0000-0002-8815-2804)
Institutions
- University of Utah (US)
- Drexel University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1093/bjd/ljaf488
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00