NOTCH1 and UPR signaling in embryonic heart development under maternal high-fat diet influence
Maternal HFD before and during pregnancy induces abnormal embryonic heart development, likely via IRE1α pathway activation in the UPR, which suppresses NOTCH1 expression and promotes apoptosis. These findings underscore the importance of a balanced maternal diet for proper embryonic heart development.
Authors
- Bingyu Li (ORCID: https://orcid.org/0000-0002-5377-3635)
- Qingyun Shi (ORCID: https://orcid.org/0000-0002-8213-1340)
- Yibing Shi (ORCID: https://orcid.org/0000-0003-4954-313X)
Institutions
- Capital Medical University (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fmed.2025.1620495
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00