Association between constipation and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies
Our meta-analysis identified a significant positive association between constipation and CHD risk, particularly myocardial infarction. These findings suggest that constipation may either accelerate the pathological processes underlying CHD or that both conditions share common etiological pathways, warranting further mechanistic and interventional studies.
Authors
- Tianjun Zhao
- Feng Tang (ORCID: https://orcid.org/0000-0001-9522-9649)
- Peiwen Dong (ORCID: https://orcid.org/0000-0002-8031-6464)
- Kan Sun (ORCID: https://orcid.org/0000-0002-3952-9871)
- Xiaobin Sun (ORCID: https://orcid.org/0000-0002-9633-4691)
- Qiong Wang
Institutions
- Third People's Hospital of Chengdu (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fcvm.2025.1622801
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00