Non-linear association of the alanine aminotransferase to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease: a secondary analysis of a Chinese cohort
The ALT/HDL-C ratio is independently and nonlinearly associated with NAFLD in Chinese adults, with a particularly strong association in non-elderly individuals and women. This simple and readily available biomarker shows promise for enhancing NAFLD risk stratification in middle-aged adults, while its utility in the elderly population may be limited and requires further investigation.
Authors
- Ziyang Huang (ORCID: https://orcid.org/0000-0002-2683-7496)
- Xiaoqing Lin (ORCID: https://orcid.org/0000-0002-1751-5348)
- Junjie Huang (ORCID: https://orcid.org/0000-0002-1996-8068)
- Yanmeng Peng
Institutions
- Chinese University of Hong Kong (HK)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fmed.2025.1713878
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00