Non-linear association of the alanine aminotransferase to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease: a secondary analysis of a Chinese cohort

The ALT/HDL-C ratio is independently and nonlinearly associated with NAFLD in Chinese adults, with a particularly strong association in non-elderly individuals and women. This simple and readily available biomarker shows promise for enhancing NAFLD risk stratification in middle-aged adults, while its utility in the elderly population may be limited and requires further investigation.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-12-04
DOI
https://doi.org/10.3389/fmed.2025.1713878
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Non-linear association of the alanine aminotransferase to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease: a secondary analysis of a Chinese cohort

Ziyang Huang, Xiaoqing Lin, Junjie Huang, Yanmeng Peng
Frontiers in Medicine
Liver Disease Diagnosis and Treatment
article

Non-linear association of the alanine aminotransferase to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease: a secondary analysis of a Chinese cohort

Ziyang Huang, Xiaoqing Lin, Junjie Huang, Yanmeng Peng
article en

Abstract

The ALT/HDL-C ratio is independently and nonlinearly associated with NAFLD in Chinese adults, with a particularly strong association in non-elderly individuals and women. This simple and readily available biomarker shows promise for enhancing NAFLD risk stratification in middle-aged adults, while its utility in the elderly population may be limited and requires further investigation.

Frontiers in MedicineVol. 12
Chinese University of Hong Kong (HK), Shantou University (CN), First Affiliated Hospital of Shantou University Medical College (CN), Shantou Central Hospital (CN)
Openalex Percentile: Top 50%
Liver Disease Diagnosis and Treatment
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Non-linear association of the alanine aminotransferase to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease: a secondary analysis of a Chinese cohort — Ziyang Huang, Xiaoqing Lin, et al. · Frontiers in Medicine (2025) | TGRS Research Map | TGRS