Impact of V179D/E mutations on antiretroviral therapy outcomes in people living with HIV-1: a 3-year retrospective study
V179D/E is highly prevalent among ART-naïve PLWH in Guangzhou and may impair early virological response to NNRTI-based regimens, particularly EFV-based regimens while increasing ADR risk.
Authors
- Linghua Li (ORCID: https://orcid.org/0000-0001-5711-8681)
- Xiejie Chen (ORCID: https://orcid.org/0009-0004-3398-1543)
- Weiping Cai (ORCID: https://orcid.org/0000-0002-1287-0623)
- Yun Lan (ORCID: https://orcid.org/0000-0002-9783-4268)
- Shiyun Lv (ORCID: https://orcid.org/0000-0001-8779-9430)
- Junbin Li
- Yonghong Li (ORCID: https://orcid.org/0000-0001-7326-0717)
- Xiaoping Tang (ORCID: https://orcid.org/0000-0001-8365-3610)
- Jingliang Chen (ORCID: https://orcid.org/0000-0003-0719-7611)
- Quanmin Li (ORCID: https://orcid.org/0000-0001-9355-8887)
- Xuemei Ling
- Chunyan Wen
Institutions
- Guangzhou Eighth People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fcimb.2025.1691715
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China