Changes in circulating NK and innate-like T cells in type 1 and type 2 diabetes
In this pilot study, we provide evidence that different subpopulations of NK cells and innate-like T cells are involved in the immunopathogenesis of T1D and T2D, through a decline in the control of immune reactivity in T1D, while sustaining chronic metainflammatory responses in T2D. A critical elevation of CD8+ NK cells was associated with T1D, while loss of circulating MAIT cells was a hallmark of T2D.
Authors
- А. В. Сорокина (ORCID: https://orcid.org/0000-0002-9600-7244)
- Р. И. Хусаинова (ORCID: https://orcid.org/0000-0002-8643-850X)
- И. И. Дедов (ORCID: https://orcid.org/0000-0002-8175-7886)
- Gennady Bocharov (ORCID: https://orcid.org/0000-0002-5049-0656)
- Nikita A. Sergeev
- A. O. Goncharenko (ORCID: https://orcid.org/0000-0001-6927-9319)
- Margarita Samsonova (ORCID: https://orcid.org/0000-0003-2852-807X)
- Д. Н. Лаптев (ORCID: https://orcid.org/0000-0002-4316-8546)
- I.I. Golodnikov (ORCID: https://orcid.org/0000-0003-0935-9004)
- Илдар Минниахметов (ORCID: https://orcid.org/0000-0002-7045-8215)
- Dmitry Grebennikov (ORCID: https://orcid.org/0000-0002-7315-193X)
- Marina Loguinova (ORCID: https://orcid.org/0000-0003-3775-4466)
- Марина Владимировна Шестакова
- Natalia Mokrysheva (ORCID: https://orcid.org/0000-0003-2604-8347)
Institutions
- Endocrinology Research Center (RU)
- Institute of Experimental Cardiology (RU)
- Research Center of Neurology (RU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1667888
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80