CXCL9 and CXCL10 support the exacerbated humoral response in recovered COVID-19 patients who developed acute respiratory distress syndrome by promoting plasma cell differentiation, whereas CXCL9 also induces CD40L and CXCR3 upregulation on T helper c
Four months after COVID-19, patients with prior ARDS and persistent pulmonary sequelae exhibit sustained elevations of anti-SARS-CoV-2 IgG and chemokines CXCL9 and CXCL10. Both chemokines directly enhance B cell differentiation into IgG-secreting plasma cells <i>in vitro</i>, while CXCL9 also increases CD4<sup>+</sup> T cell help, suggesting a mechanistic link between chronic inflammation, increased humoral responses, and long-term lung impairment. Targeting CXCL9/CXCL10-CXCR3 signaling could offer therapeutic potential to mitigate post-COVID pulmonary complications.
Authors
- Gonzalo Labarca (ORCID: https://orcid.org/0000-0002-0069-3420)
- Catarina Sepúlveda (ORCID: https://orcid.org/0000-0003-3253-1968)
- Mario Henríquez‐Beltrán (ORCID: https://orcid.org/0000-0002-7179-0690)
- Marco Fraga
- Luciano Ferrada (ORCID: https://orcid.org/0000-0001-5478-2325)
- Faryd Llerena
- Sergio Manuel Rivera Sanhueza (ORCID: https://orcid.org/0000-0002-6867-2511)
- Camilo Cabrera
- Liliana Lamperti
- Alicia Colombo (ORCID: https://orcid.org/0000-0002-2690-146X)
- Romina Andrea Quiroga
- María Inés Barría (ORCID: https://orcid.org/0000-0001-6225-5971)
- Camila Muñoz (ORCID: https://orcid.org/0000-0003-3058-4273)
- Estefanía Nova‐Lamperti (ORCID: https://orcid.org/0000-0002-7673-0013)
- Bárbara Antilef (ORCID: https://orcid.org/0009-0007-0375-1968)
Institutions
- Brigham and Women's Hospital (US)
- University of Concepción (CL)
- Instituto de Salud Carlos III (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- San Sebastián University (CL)
- Universidad Santo Tomás (CL)
- Universidad Adventista de Chile (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Complejo Asistencial Sótero del Río (CL)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- University of Chile (CL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1684704
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Universidad de Chile
- Agencia Nacional de Investigación y Desarrollo
- Instituto de Salud Carlos III