Advancing breast cancer biomarkers: a centromere-related gene signature integrated with single-cell analysis for prognostic prediction
This study is the first to establish a CENP-based prognostic model for BC, offering novel biomarkers and potential therapeutic targets for personalized treatment. Additionally, the biological function of the key molecule MMP1 was validated through both <i>in vitro</i> and <i>in vivo</i> experiments.
Authors
- Kan Yonemori (ORCID: https://orcid.org/0000-0002-7624-7611)
- Shengbin Pei
- Xiangyi Kong (ORCID: https://orcid.org/0000-0002-8209-042X)
- Xiangyu Wang (ORCID: https://orcid.org/0000-0001-9357-4481)
- Jing Wang (ORCID: https://orcid.org/0000-0002-3224-3993)
- Wenxiang Zhang (ORCID: https://orcid.org/0000-0002-1077-8014)
- Ye Lu (ORCID: https://orcid.org/0009-0007-5957-5596)
- Siqing Liu (ORCID: https://orcid.org/0000-0002-7235-1075)
- Jidong Gao
- Hao Dong (ORCID: https://orcid.org/0000-0002-1193-3987)
- Zheng Qu
- Yi Fang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- National Cancer Center Hospital East (JP)
- Tokyo National Hospital (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1678603
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00