Physiologically-based pharmacokinetic modeling and simulation for initial dose optimization of levetiracetam in pediatrics
The combined PBPK-MLR approach provides a robust, data-driven framework to support rational first-dose prescriptions of LEV in children. This tool has the potential to accelerate therapeutic effects while enhancing treatment individualization. Prospective clinical validation is required to confirm the model predictive performance for drug exposure and, consequently, its impact on therapeutic efficacy.
Authors
- Edilainy Rizzieri Caleffi (ORCID: https://orcid.org/0000-0002-8806-3158)
- Julia Macente (ORCID: https://orcid.org/0000-0002-4452-5867)
- Rodolfo Hernandes Bonan (ORCID: https://orcid.org/0000-0001-5944-2602)
- Pieter Annaert (ORCID: https://orcid.org/0000-0003-3525-7351)
- Leonardo Régis Leira Pereira (ORCID: https://orcid.org/0000-0002-8609-1390)
- Andréa Diniz (ORCID: https://orcid.org/0000-0002-9638-9246)
- Karel Allegaert (ORCID: https://orcid.org/0000-0001-9921-5105)
- Priscila Machado Vieira Lima
Institutions
- Universidade Estadual de Maringá (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Erasmus MC (NL)
- Centro Universitário Barão de Mauá (BR)
- Nanotechnology Industries Association (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fphar.2025.1678960
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação Araucária