PFKFB3 alleviates the advancement of Fusarium solani keratitis by attenuating macrophage inflammation
In <i>F. solani</i>-infected corneas and BMDM, the glycolysis rate-limiting enzyme PFKFB3 was markedly upregulated. After infection, moderate PFKFB3 activation effectively mitigates inflammation and the progression of fungal keratitis. Moreover, activated PFKFB3 may rely on the PI3K/AKT/NF-κB p65 signaling pathway to safeguard the cornea from further damage due to inflammation.
Authors
- Jianzhang Hu (ORCID: https://orcid.org/0000-0003-0610-7856)
- Hanfeng Tang
- Yanqing Zhang (ORCID: https://orcid.org/0000-0001-9830-0535)
- Yani Zhang (ORCID: https://orcid.org/0000-0002-1148-9660)
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fcimb.2025.1623027
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00