Elevated miR-17-5p facilitates mycobacterial immune evasion by targeting MAP3K2 in macrophages
miR-17-5p promotes <i>M. avium</i> survival by targeting MAP3K2 and suppressing MAPK-dependent immune functions in macrophages. These findings highlight miR-17-5p as a potential diagnostic biomarker and therapeutic target in TB and related mycobacterial infections.
Authors
- Dehui Xiong
- Yiyue Tang
- Jinlan Yang
- Peilei Hu (ORCID: https://orcid.org/0000-0001-8252-848X)
- Lijun Tang
- Xichang Tang
- Md Shoykot Jahan
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Changsha Normal University (CN)
- Hunan Province Chest Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1676204
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79