Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer
EOCRC and LOCRC involved different immune mechanisms, where EOCRC showed an altered proinflammatory environment with preserved regulatory pathways, while LOCRC reflected age-related immune decline and inflammaging. Peripheral blood immune profiling offers a minimally invasive liquid Immunoscore for early detection and enables personalized immunotherapies for age-related immune landscapes, particularly benefiting younger individuals at risk of EOCRC.
Authors
- José Perea (ORCID: https://orcid.org/0000-0001-5522-8844)
- Mayte Coiras (ORCID: https://orcid.org/0000-0001-6464-5770)
- Valentina Leguizamon
- Antonino Spinelli (ORCID: https://orcid.org/0000-0002-1493-1768)
- Miguel Cervero (ORCID: https://orcid.org/0000-0001-9387-7917)
- Edurne Álvaro (ORCID: https://orcid.org/0000-0001-6793-3188)
- Montserrat Torres (ORCID: https://orcid.org/0000-0001-8776-8925)
- Elena Hurtado-Caballero
- Francesc Balaguer (ORCID: https://orcid.org/0000-0002-0206-0539)
- José A. Rueda (ORCID: https://orcid.org/0000-0003-3558-3755)
- Clara Sánchez-Menéndez (ORCID: https://orcid.org/0000-0002-9856-6349)
- Marc Martí-Gallostra
- Esther San José
- Elena Mateos (ORCID: https://orcid.org/0000-0002-5449-7337)
- Daniel Fuertes (ORCID: https://orcid.org/0000-0002-5746-2199)
- Jorge Martı́nez-Laso (ORCID: https://orcid.org/0000-0001-5778-8108)
- José Manuel Rodrı́guez-Pérez (ORCID: https://orcid.org/0000-0002-3802-0897)
- Araceli Ballestero-Pérez
- Carlos Pastor (ORCID: https://orcid.org/0000-0001-8454-6390)
- Gonzalo Sanz (ORCID: https://orcid.org/0000-0003-3747-2282)
- María González-Sanmartin
Institutions
- Universidad Complutense de Madrid (ES)
- Universitat Autònoma de Barcelona (ES)
- Humanitas University (IT)
- Universidad Nacional de Educación a Distancia (ES)
- Universidad de Alcalá (ES)
- Instituto Cajal (ES)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Hospital Clínic de Barcelona (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Clinica Universidad de Navarra (ES)
- Universidad Alfonso X el Sabio (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hospital Universitario Ramón y Cajal (ES)
- IRCCS Humanitas Research Hospital (IT)
- Hospital Universitario Infanta Leonor (ES)
- Universitat de Barcelona (ES)
- Universidad Politécnica de Madrid (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1692382
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comunidad de Madrid
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación