A food-medicine homology formulation ameliorates atherosclerosis by attenuating dyslipidemia and inflammation via the PI3K/Akt/NF-κB pathway
YTT ameliorates atherosclerosis by counteracting dyslipidemia and inflammation, primarily through modulation of the PI3K/Akt/NF-κB pathway. This study offers novel integrative insights into the anti-atherogenic properties of YTT and pinpoint crucial bioactive constituents worthy of further pharmacological investigation.
Authors
- Shuo Zhang (ORCID: https://orcid.org/0000-0002-5129-3590)
- Junsong Jing
- Yadong Zheng (ORCID: https://orcid.org/0000-0001-6795-9978)
- Liguo Li (ORCID: https://orcid.org/0000-0002-9945-5771)
- Zhihao Zhou
- Junfeng Lu (ORCID: https://orcid.org/0000-0002-2640-8595)
- Christian Hölscher (ORCID: https://orcid.org/0000-0002-8159-3260)
- Yi Li (ORCID: https://orcid.org/0000-0002-2092-4505)
- Wenlong Chen (ORCID: https://orcid.org/0000-0002-5858-8463)
Institutions
- Henan Academy of Sciences (CN)
- Henan Energy & Chemical Industry Group (China) (CN)
- Beike Biotechnology (China) (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fphar.2025.1710585
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 0.00