Circulating microbiome profiling in transjugular intrahepatic portosystemic shunt patients: 16S rRNA vs. shotgun sequencing

In our study, 16S rRNA amplicon sequencing captured more diverse microbial signals than shotgun metagenomics. A stable microbial community structure was observed across vascular compartments, suggesting a homogeneous microbial composition throughout the circulatory system.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-12-04
DOI
https://doi.org/10.3389/fmed.2025.1662837
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
0.00
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article

Circulating microbiome profiling in transjugular intrahepatic portosystemic shunt patients: 16S rRNA vs. shotgun sequencing

Lingxuan Ren, Meng‐Yao Lu, Yan Tian, Xiaohui Huo et al.
Frontiers in Medicine
Liver Disease and Transplantation
article

Circulating microbiome profiling in transjugular intrahepatic portosystemic shunt patients: 16S rRNA vs. shotgun sequencing

Lingxuan Ren, Meng‐Yao Lu, Yan Tian, Xiaohui Huo, Huimin Zhao, Guifen Liu, L. Du, Chao Xu, Jiale Xie, Chao Zhu, Menghui Xu, Xuechen Liu, Changshun Xie, J Matsubara, Xiaoxu Jin, Jingxiang Zhang, Zi-Lin Ma, Chang He, Xin Wang, Lei Chen, Wei Chen, Xiaowen Wang, Xueqiang Zhang, Jiale Liu, Zhijie Feng, Xiaoshuang Xu, Xincheng Yang, Jiahua Liu, Wei Qi, Guoqi Zheng
article en

Abstract

In our study, 16S rRNA amplicon sequencing captured more diverse microbial signals than shotgun metagenomics. A stable microbial community structure was observed across vascular compartments, suggesting a homogeneous microbial composition throughout the circulatory system.

Frontiers in MedicineVol. 12
Hebei Medical University (CN), Handan College (CN), Faculdade de Medicina de Marília (BR), Chinese University of Hong Kong (HK), Second Hospital of Hebei Medical University (CN), Cangzhou Central Hospital (CN), Fourth Hospital of Hebei Medical University (CN), Hebei General Hospital (CN), Xingtai People's Hospital (CN), First Affiliated Hospital of Hebei Medical University (CN), First Hospital of Qinhuangdao (CN)
Openalex Percentile: Top 50%
Liver Disease and Transplantation
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