Fourier transform infrared spectroscopy detects distinct TAR DNA-binding protein 43 signatures in frontotemporal lobar degeneration
Fourier transform infrared spectroscopy of FFPE brain tissue sections from FTLD[TDP] and AD captures disease-specific changes in the composition of proteins, lipids, and secondary structures. These findings suggest that FTIR spectroscopy can serve as a rapid and cost-effective tool for mapping and quantitating biomolecular alterations in FTLD.
Authors
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Oleksandr Gakh (ORCID: https://orcid.org/0000-0003-3708-1118)
- Jordan Wilkins
- Claudia F. Lucchinetti (ORCID: https://orcid.org/0000-0001-5070-1196)
- Arenn F. Carlos (ORCID: https://orcid.org/0000-0002-2100-5033)
- Rodolfo G. Gatto (ORCID: https://orcid.org/0000-0003-2170-6662)
- Hossam Youssef (ORCID: https://orcid.org/0009-0000-8876-8038)
- Jennifer L. Whitwell (ORCID: https://orcid.org/0000-0001-6914-1563)
- Yong Guo (ORCID: https://orcid.org/0000-0001-6485-7925)
Institutions
- Mayo Clinic in Arizona (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fnins.2025.1649433
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health