Significant Antispastic Effect of Combined Fasudil and Isosorbide Dinitrate on Internal Mammary Artery in Coronary Artery Bypass Grafting
The combination of fasudil and ISDN effectively prevents and relieves IMA vasospasm mediated by both voltage-operated and receptor-operated calcium channels, with a long-lasting vasorelaxing effect. The FI solution offers a novel approach for preventing and relieving IMA spasm in CABG.
Authors
- Hai‐Tao Hou
- Guo‐Wei He (ORCID: https://orcid.org/0000-0001-6497-876X)
- Qin Yang (ORCID: https://orcid.org/0000-0002-9792-4431)
- Y Y Zhang
Institutions
- Tianjin University (CN)
- Oregon Health & Science University (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- TEDA International Cardiovascular Hospital (CN)
Publication Details
- Journal
- Basic & Clinical Pharmacology & Toxicology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1111/bcpt.70148
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tianjin Municipal Health Commission
- National Natural Science Foundation of China