Primary mucinous sarcoma of the lung with EWSR1 translocation: a case report

Primary pulmonary myxoid sarcoma (PPMS) is an extremely rare lung sarcoma with a low incidence. It is a low-grade malignant tumor with histological and molecular features similar to those of extranodal myxoid chondrosarcoma. To date, it has been reported less frequently. We report a case of primary mucinous sarcoma of the lung with EWSR1 translocation, which was definitively diagnosed by bronchoscopic biopsy. Biopsy tissues were tested for pathology, immunohistochemistry, and molecular pathology. Additionally, fluorescence <i>in situ</i> hybridisation was performed using an EWSR1 breakthrough probe. The patient's left common branch was obstructed by a neoplasm, which was identified during bronchoscopy. A tracheoscopic circling procedure was then performed. The patient underwent a small-incision sleeve resection of the lower lobe of the left lung and lymph node dissection with the assistance of video-assisted thoracic surgery (VATS) under general anesthesia. The patient had a good postoperative recovery, and a follow-up chest CT at 2 months after the operation showed no signs of recurrence.