Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers
Neutrophil-driven immune dysregulation, with TNF-α-polarized neutrophils and APP-CD74 signaling, contributes to RM pathogenesis. CXCL1 and related genes serve as promising biomarkers, offering new opportunities for early diagnosis and therapeutic intervention.
Authors
- Fei Ma (ORCID: https://orcid.org/0000-0001-9432-1902)
- Jiaman Wu (ORCID: https://orcid.org/0000-0001-9381-7711)
- Yan Ning (ORCID: https://orcid.org/0000-0002-5159-6647)
- Ke-Wang Luo
- Liang Qi (ORCID: https://orcid.org/0009-0001-4237-5201)
- Meng Yu (ORCID: https://orcid.org/0000-0002-4765-6109)
- Hong Chang (ORCID: https://orcid.org/0000-0003-0965-9090)
- Yabin Gong (ORCID: https://orcid.org/0000-0002-6811-101X)
- Shan He (ORCID: https://orcid.org/0009-0003-5844-4755)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1707497
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80