Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development
Exposure to multiple EDCs may disrupt distinct endocrine axes, producing cumulative impacts on human brain development. These findings underscore the value of human-relevant models for identifying endocrine-mediated neurodevelopmental hazards. While the observed molecular changes suggest distinct hormonal pathways may be involved, future mechanistic studies, including co-exposures with receptor modulators, will be required to establish causal relationships.
Authors
- Angela Di Baldassarre (ORCID: https://orcid.org/0000-0002-4473-4909)
- Timothy A. Blenkinsop (ORCID: https://orcid.org/0000-0002-8095-9937)
- Barbara Ghinassi (ORCID: https://orcid.org/0000-0002-3529-2790)
- Stefano Bibbò (ORCID: https://orcid.org/0000-0002-8043-4807)
- Andrea Di Credico (ORCID: https://orcid.org/0000-0002-8388-9305)
- Giulia Gaggi (ORCID: https://orcid.org/0000-0002-8761-7390)
Institutions
- University of Chieti-Pescara (IT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fendo.2025.1692333
- Citations
- 1
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 3.49