A novel rhein derivative Y01 inhibits hepatocellular carcinoma by inducing apoptosis through regulating PI3K/AKT/mTOR pathway
Y01 inhibited the proliferation, migration, and induced apoptosis of HCC cells possibly by blocking PI3K/AKT/mTOR signaling pathway.
Authors
- Wei Tian (ORCID: https://orcid.org/0000-0002-1659-2210)
- Mingyu Ji
- Mulan Li
- Lei Yang (ORCID: https://orcid.org/0000-0002-9039-8520)
- Tingting Yang (ORCID: https://orcid.org/0000-0002-6815-2970)
- Zhihong Zhou (ORCID: https://orcid.org/0000-0003-2144-2804)
- Limei Yang (ORCID: https://orcid.org/0000-0002-6781-5760)
- Peilin Yang (ORCID: https://orcid.org/0009-0002-6368-2574)
- Ran Dong
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Guangxi Zhuang Autonomous Region Department of Education (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
- Nanxi Mountain Hospital (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1093/jpp/rgaf120
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00