Whole genome sequencing and phylogenetic analysis of the equine infectious anemia virus associated with 2017 Spain outbreaks

In 2017, Spain reported its first equine infectious anemia virus (EIAV) outbreak in 34 years, affecting three horses in two unrelated holdings in Candeleda (Ávila) and Serradilla (Cáceres), with no apparent epidemiological link between premises. Phylogenetic analysis of whole genome and the gag gene revealed that the Spanish EIAV strains form a distinct monophyletic clade, sharing more than 99% nucleotide identity, suggesting a common contamination event. Interestingly, these three viral strains seem to cluster with North American strains, sharing up to 80.12% nucleotide identity, notably with the Wyoming strain, marking the first such association for European strains. These findings raise important questions regarding the potential routes of EIAV introduction into Spain and highlight the need for enhanced surveillance and genomic characterization to better understand viral transmission dynamics.

Authors

Institutions

Publication Details

Journal
BMC Veterinary Research
Published
2025-12-04
DOI
https://doi.org/10.1186/s12917-025-05100-4
Primary Topic
Animal Virus Infections Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Whole genome sequencing and phylogenetic analysis of the equine infectious anemia virus associated with 2017 Spain outbreaks

Eva García, Fanny Lecouturier, Germán Cáceres, Nicolás Berthet et al.
BMC Veterinary Research
Animal Virus Infections Studies
article

Whole genome sequencing and phylogenetic analysis of the equine infectious anemia virus associated with 2017 Spain outbreaks

Eva García, Fanny Lecouturier, Germán Cáceres, Nicolás Berthet, Delphine Froger, José Carlos Valle‐Casuso, Yannick Blanchard, Montserrat Agüero, Fabrice Touzain, Aymeric Hans, Alexandre Deshière, R. de la Haza, N. Wiernasz
article en

Abstract

In 2017, Spain reported its first equine infectious anemia virus (EIAV) outbreak in 34 years, affecting three horses in two unrelated holdings in Candeleda (Ávila) and Serradilla (Cáceres), with no apparent epidemiological link between premises. Phylogenetic analysis of whole genome and the gag gene revealed that the Spanish EIAV strains form a distinct monophyletic clade, sharing more than 99% nucleotide identity, suggesting a common contamination event. Interestingly, these three viral strains seem to cluster with North American strains, sharing up to 80.12% nucleotide identity, notably with the Wyoming strain, marking the first such association for European strains. These findings raise important questions regarding the potential routes of EIAV introduction into Spain and highlight the need for enhanced surveillance and genomic characterization to better understand viral transmission dynamics.

BMC Veterinary ResearchVol. 22(1)
Institut Pasteur (FR), École nationale d'ingénieurs de Brest (FR), Département Santé Animale (FR), Ministère de l'Agriculture et de la Souveraineté alimentaire (FR), Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR), Ministerio de Agricultura, Pesca y Alimentación (ES), Newmarket Equine Hospital (GB)
Openalex Percentile: Top 56%
Animal Virus Infections Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.