Fcγ-receptor-activation by circulating immune complexes in systemic autoimmune diseases and its reduction by CD19-CAR T cell therapy
Our study reveals the presence of FcγR-engaging cICs in CTDs and demonstrates that the bioactivity of cICs is correlated with clinical phenotypes and treatment outcomes.
Authors
- Luis E. Muñoz (ORCID: https://orcid.org/0000-0002-5395-804X)
- Maren Claus (ORCID: https://orcid.org/0000-0001-8732-0645)
- Jörg H. W. Distler (ORCID: https://orcid.org/0000-0001-7408-9333)
- Ayla Nadja Stütz
- Ivana Andreeva
- Wolfgang Merkt (ORCID: https://orcid.org/0000-0002-3108-154X)
- Ricardo Grieshaber‐Bouyer (ORCID: https://orcid.org/0000-0002-2873-5135)
- Norbert Blank (ORCID: https://orcid.org/0000-0002-9419-1690)
- Valeria Falcone (ORCID: https://orcid.org/0000-0003-1180-8737)
- Philipp Kolb (ORCID: https://orcid.org/0000-0001-7935-217X)
- Georg Andreas Schett (ORCID: https://orcid.org/0000-0001-8740-9615)
- Paul M. Schroder
- Lea Rodon
- Franca Sophie Deicher
- Hanns-Martin Lorenz
- Merle Freitag
- Meike Ewald
Institutions
- University of Freiburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- TU Dortmund University (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/rheumatology/keaf627
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00