Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections

Our findings suggest that the proposed predictive cut-off risk score may represent a valuable tool for identifying promptly critically ill patients at high risk of early aggressive PK/PD target non-attainment with CI piperacillin-tazobactam or meropenem for whom a more intensified CI dosing regimens should be promptly applied bedside.

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Publication Details

Journal
Journal of Anesthesia Analgesia and Critical Care
Published
2025-12-04
DOI
https://doi.org/10.1186/s44158-025-00324-0
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
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article

Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections

Pierantonio Grimaldi, Tommaso Tonetti, Milo Gatti, Antonio Daniele Pinna et al.
Journal of Anesthesia Analgesia and Critical Care
Antibiotics Pharmacokinetics and Efficacy
article

Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections

Pierantonio Grimaldi, Tommaso Tonetti, Milo Gatti, Antonio Daniele Pinna, Federico Pea, Matteo Rinaldi, Pierluigi Viale
article en

Abstract

Our findings suggest that the proposed predictive cut-off risk score may represent a valuable tool for identifying promptly critically ill patients at high risk of early aggressive PK/PD target non-attainment with CI piperacillin-tazobactam or meropenem for whom a more intensified CI dosing regimens should be promptly applied bedside.

Journal of Anesthesia Analgesia and Critical CareVol. 6(1)
University of Campania "Luigi Vanvitelli" (IT), Azienda USL di Bologna (IT), University of Bologna (IT)
Openalex Percentile: Top 59%
Antibiotics Pharmacokinetics and Efficacy
DOIOpen Access PDFOpenAlex
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Validation of a predictive risk score of aggressive PK/PD target non-attainment with continuous infusion piperacillin/tazobactam or meropenem in critically ill patients having documented Gram-negative infections — Pierantonio Grimaldi, Tommaso Tonetti, et al. · Journal of Anesthesia Analgesia and Critical Care (2025) | TGRS Research Map | TGRS