Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment
Collectively, these findings establish a phosphoinositide- and cytoskeleton-guided mechanism that governs myosin-1 isoform-specific functions, providing new insights into how motor proteins interpret complex lipid and cytoskeletal cues to regulate membrane remodelling and cytoskeletal dynamics across cellular states.
Authors
- Girish Rajendraprasad (ORCID: https://orcid.org/0000-0003-2521-3005)
- Georgios Tsiavaliaris (ORCID: https://orcid.org/0000-0002-5161-4884)
- Petra Uta
- Almke Bader (ORCID: https://orcid.org/0000-0003-2313-598X)
- Muriel Erent (ORCID: https://orcid.org/0000-0003-2526-4574)
- Peter Franz (ORCID: https://orcid.org/0000-0001-9770-743X)
- Matthias Preller (ORCID: https://orcid.org/0000-0002-7784-4012)
- Tim Scholz (ORCID: https://orcid.org/0000-0002-2127-9843)
- Despoina Kyriazi (ORCID: https://orcid.org/0009-0000-6302-7794)
Institutions
- Hochschule Bonn-Rhein-Sieg (DE)
- Medizinische Hochschule Hannover (DE)
- University of Warwick (GB)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s12964-025-02528-x
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00