Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation
ADAM15 is a previously unknown regulator of necroptosis, likely due to its role in modulating intracellular organelle sorting processes. Its proteolytic activity and possible scaffolding capacity for recruiting adaptor molecules make it a veritable drug target. The activation or deactivation of ADAM15 may be exploited to modulate various disease conditions.
Authors
- Andreas Walter (ORCID: https://orcid.org/0000-0002-4096-1944)
- Julia Frankenheim
- Ute Distler (ORCID: https://orcid.org/0000-0002-8031-6384)
- Sebastian Braun (ORCID: https://orcid.org/0000-0003-4175-8718)
- Tanja Ziesmann (ORCID: https://orcid.org/0009-0009-0399-258X)
- Jürgen H. Fritsch (ORCID: https://orcid.org/0000-0001-6909-6096)
- Wulf Schneider‐Brachert (ORCID: https://orcid.org/0000-0002-2707-2923)
- K. Knackfuß
- A. Goerg
- L. Mlinzk
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Hospital Regensburg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s12964-025-02530-3
- Citations
- 1
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81