Clinicopathologic and Molecular Characterization of Colorectal Cancer in Patients Aged ≥80 years
CRC patients aged ≥80 years exhibit higher dMMR rates and shorter DFS, with molecular features of immunosuppression, ECM remodeling, and enhanced neural-tumor interactions, challenging the assumption of slow CRC progression in very older patients. These findings provide basis for personalized treatment strategies in this underrepresented and growing population.
Authors
- Xuan Lai
- Wei Fu (ORCID: https://orcid.org/0000-0001-5248-7891)
- Zimin Zhao
- Xin Zhou (ORCID: https://orcid.org/0000-0002-9362-8272)
- Ziyue Zhang (ORCID: https://orcid.org/0000-0002-6050-779X)
- Renjie Luo
- Fan Zhang (ORCID: https://orcid.org/0000-0002-6840-3768)
- Yao Ma (ORCID: https://orcid.org/0000-0003-1476-5285)
- Xiangchao Shi (ORCID: https://orcid.org/0000-0002-1212-0232)
- Junwei Wang (ORCID: https://orcid.org/0009-0002-1404-9983)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University Third Hospital (CN)
- South China Institute of Collaborative Innovation (CN)
Publication Details
- Journal
- Clinical Interventions in Aging
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/cia.s565139
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University
- Peking University Third Hospital