ChatGPT-Assisted Glaucoma Diagnosis: A Health-Equitable Multi-Ancestry Analysis Using Visual Field and Optical Coherence Tomography Data
ChatGPT o1 Pro diagnosed glaucoma similarly to specialists using only VF and OCT data. The model performance was similar across ancestral groups and genetic predispositions to glaucoma.
Authors
- Louis R. Pasquale (ORCID: https://orcid.org/0000-0002-5835-3496)
- Jae H. Kang (ORCID: https://orcid.org/0000-0003-4812-0557)
- N. Paulescu
- Tak Yee Tania Tai (ORCID: https://orcid.org/0000-0002-6383-0234)
- James C. Tsai (ORCID: https://orcid.org/0000-0002-5873-423X)
- Alon Harris (ORCID: https://orcid.org/0000-0001-8770-3726)
- Tobias Elze (ORCID: https://orcid.org/0000-0002-2032-0496)
- Nazlee Zebardast (ORCID: https://orcid.org/0000-0003-1763-9401)
- Anthony Fam (ORCID: https://orcid.org/0000-0003-3530-8219)
- Kanza Aziz (ORCID: https://orcid.org/0000-0001-9147-9122)
- Anna Fabczak-Kubicka (ORCID: https://orcid.org/0000-0002-0624-3682)
- David Steven Friedman (ORCID: https://orcid.org/0000-0002-2055-5797)
- Andy Huang (ORCID: https://orcid.org/0000-0003-4576-9748)
- Ron Do (ORCID: https://orcid.org/0000-0002-3144-3627)
- Janey L. Wiggs (ORCID: https://orcid.org/0000-0003-1890-3278)
- Mengyu Wang (ORCID: https://orcid.org/0009-0003-3104-7725)
- Huijuan Zhao (ORCID: https://orcid.org/0000-0001-6738-1141)
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- New York Eye and Ear Infirmary (US)
- Child Health and Development Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.ajo.2025.11.046
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- Glaucoma Foundation
- New York Eye and Ear Infirmary of Mount Sinai
- American Academy of Ophthalmology
- National Institutes of Health
- National Eye Institute