Tetramethylpyrazine alleviates ventricular remodeling after myocardial infarction by regulating Sirt1/p300/Yy1/sST2 signaling axis
We found that increased serum sST2 levels were significantly correlated with the progression of adverse ventricular remodeling following MI. Furthermore, our study provides the first preclinical evidence demonstrating that TMPZ attenuates this remodeling process by targeting the Sirt1/p300/Yy1/sST2 signaling axis. Collectively, these findings not only highlight sST2 as a promising therapeutic target but also establish a mechanistic rationale for developing novel interventions through pharmacological modulation of the Sirt1/sST2 pathway.
Authors
- Rui Zhang (ORCID: https://orcid.org/0000-0002-8655-4017)
- Yuhong Fan (ORCID: https://orcid.org/0000-0003-1027-0795)
- Shaoxia Wang (ORCID: https://orcid.org/0000-0002-1762-8684)
- Zhirui Fang
- Hong Wang (ORCID: https://orcid.org/0000-0002-6192-3082)
- Tianyu Wang (ORCID: https://orcid.org/0000-0003-4169-8268)
- Ting Liu (ORCID: https://orcid.org/0000-0002-6655-2356)
- Lu Chen (ORCID: https://orcid.org/0000-0001-9347-291X)
- Ping Liu (ORCID: https://orcid.org/0000-0002-5315-9088)
- Ning Liu (ORCID: https://orcid.org/0000-0001-9023-4254)
- Ying Guo (ORCID: https://orcid.org/0000-0003-0851-3823)
- Xinze Li (ORCID: https://orcid.org/0000-0002-6648-1703)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.phymed.2025.157662
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00