Susceptibilities of cefiderocol, meropenem-xeruborbactam, cefepime-taniborbactam, aztreonam-avibactam, and sulbactam-durlobactam against imipenem-non-susceptible Gram-negative bacilli in Taiwan
Cefiderocol showed >90% susceptibility across all species. The susceptibilities of meropenem-xeruborbactam (XEM), cefepime-taniborbactam (FTB), and aztreonam-avibactam (AZA) were 72-96% for 29 INS-EC; 95-97% for 138 INS-KP; and 0-95% for 135 INS-AB; and 32-70% for 85 INS-PA. Sulbactam-durlobactam (SUD) was active against 93% of INS-AB. Cefiderocol, XEM, and AZA retained >80% activity against class B carbapenemase-producing INS-EC/KP. Cefiderocol, XEM, and SUD showed >90% activity against bla<sub>OXA-23/24-like</sub> INS-AB. Reduced FTB activity in INS-EC was associated with both YRIK/YRIN insertion in penicillin-binding protein 3 (PBP3) and carbapenemase genes or bla<sub>IMP</sub> alone, whereas reduced AZA activity was linked to PBP3 alteration or bla<sub>CMY-42.</sub> CONCLUSIONS: Cefiderocol was highly effective, whereas novel β-lactam/β-lactamase inhibitors activity varied by species and carbapenemase types. PBP3 alterations reduced FTB and AZA activity in INS-EC.
Authors
- Peijing Chen (ORCID: https://orcid.org/0009-0002-2828-8969)
- I‐Wen Huang
- Yih‐Ru Shiau
- Jui‐Fen Lai
- Shu‐Chen Kuo (ORCID: https://orcid.org/0000-0002-6940-6450)
- Yu-Lin Lee (ORCID: https://orcid.org/0000-0001-6346-082X)
- Ya‐Sung Yang (ORCID: https://orcid.org/0000-0001-9168-9189)
- Mei-Chen Tan
- Hui-Ying Wang
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
Institutions
- National Health Research Institutes (TW)
- Chung Shan Medical University Hospital (TW)
- National Defense Medical Center (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.ijid.2025.108279
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Tungs' Taichung MetroHarbor Hospital
- Cathay General Hospital
- Chang Gung Medical Foundation
- Kaohsiung Medical University
- National Health Research Institutes
- National Cheng Kung University Hospital
- Shionogi
- Far Eastern Memorial Hospital
- Changhua Christian Hospital
- National Cheng Kung University
- Taichung Veterans General Hospital
- Sin-Lau Hospital
- Tri-Service General Hospital
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- Taipei Veterans General Hospital
- Kaohsiung Veterans General Hospital
- Ditmanson Medical Foundation Chia-Yi Christian Hospital
- Kaohsiung Armed Forces General Hospital
- Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital
- National Science and Technology Council
- Centers for Disease Control and Prevention
- Kaohsiung Chang Gung Memorial Hospital